Selective Serotonin Reuptake Inhibitors Modify Physiological Gastrointestinal Motor Activities via 5-HT2c Receptor and Acyl Ghrelin

@article{Fujitsuka2009SelectiveSR,
  title={Selective Serotonin Reuptake Inhibitors Modify Physiological Gastrointestinal Motor Activities via 5-HT2c Receptor and Acyl Ghrelin},
  author={Naoki Fujitsuka and Akihiro Asakawa and Mizuki Hayashi and Marie Sameshima and Akio Inui},
  journal={Biological Psychiatry},
  year={2009},
  volume={65},
  pages={748-759}
}
BACKGROUND Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat anxiety and depressive disorders. These agents may cause upper gastrointestinal (GI) symptoms that lead to their discontinuation. We examined whether SSRIs modify physiologic GI motor activities in freely moving rats. METHODS The SSRIs fenfluramine, fluvoxamine, paroxetine, and fluoxetine were administered to 24-hour food-deprived rats, and then GI motility was measured in conscious, freely moving rats using a… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 35 CITATIONS

Rikkunshito, a ghrelin potentiator, ameliorates anorexia–cachexia syndrome

  • Front. Pharmacol.
  • 2014
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Rikkunshito and Ghrelin

  • International journal of peptides
  • 2010
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The Role of Ghrelin and Ghrelin Signaling in Aging

  • International journal of molecular sciences
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND