Selective Serotonin Reuptake Inhibitors Modify Physiological Gastrointestinal Motor Activities via 5-HT2c Receptor and Acyl Ghrelin

  title={Selective Serotonin Reuptake Inhibitors Modify Physiological Gastrointestinal Motor Activities via 5-HT2c Receptor and Acyl Ghrelin},
  author={Naoki Fujitsuka and Akihiro Asakawa and Mizuki Hayashi and Marie Sameshima and Haruka Amitani and Shinya Kojima and Mineko Fujimiya and Akio Inui},
  journal={Biological Psychiatry},

Anti-emetic effect of mosapride citrate hydrate, a 5-HT4 receptor agonist, on selective serotonin reuptake inhibitors (SSRIs)-induced emesis in experimental animals.

It is shown in this study that oral administration of SSRIs causes emesis and activates gastric vagal afferent activity in experimental animals and that mosapride inhibits SSR is-induced emesis, probably via improvement ofSSRIs-induced delay in gastric emptying.

Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction

Ghrelin and gastrointestinal movement.

Prokinetic meranzin hydrate from Chaihu-Shugan-San improves depression-like behaviors and hypomotility in rats via ghrelin and neurocircuitry

Data show that on acute FS-stimulated DB&H, MH-induced rapid A&P, and ghrelin-related regulation coupled to BOLD signals in brain areas before, providing insight into a unified theory of depression pathogenesis and pharmacotherapy.

Influences of Serotonin Hydrochloride on Adiponectin, Ghrelin and KiSS1 Genes Expression

The serotonergic pathway may have stimulatory effects on hypothalamic kisspeptin synthesis, partly via inhibiting hypothalamic ghrelin and adiponectin neural activity.

Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease

  • C. Yamada
  • Biology
    International journal of molecular sciences
  • 2021
The characteristics of GHS-R1a, the role of ghrelin in hypophagia due to stress or anticancer drugs, and the gender differences in the physiological effects of G HS-R 1a and the influence of stress on it are described.

The Effects of 5-Hydroxytryptamine and Interaction With Kisspeptin in Controlling Ghrelin and Adiponectin Secretion

Kisspeptin/GPR54 signaling pathway may be a putative target in serotonergic neurons to control ghrelin and adiponectin secretion in rats treated with kisspeptin or 5HT.

Preventive effect of rikkunshito on gastric motor function inhibited by l-dopa in rats

Ghrelin Gene Products and the Regulation of Food Intake and Gut Motility

Ghrelin is the only protein to be octanylated, and inhibition of GOAT may have effects only on the stomach and is unlikely to affect the synthesis of other proteins, which may provide a critical molecular target in developing novel therapeutics for obesity and type 2 diabetes.



The 5-HT3 antagonist ondansetron reduces gastrointestinal side effects induced by a specific serotonin re-uptake inhibitor in man

It is demonstrated that, in volunteers, a single 100 mg oral dose of fluvoxamine can produce GI symptoms, and co-administration of ondansetron significantly reduced peak nausea and GI side effects, compared with placebo.

Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors.

The data presented here not only indicate that the novel 5-HT(2C)R agonist BVT.X warrants further investigation as a treatment for obesity but also elucidate specific neuronal pathways potently affecting energy balance through which 5- HT( 2C) R agonists regulate ingestive behavior.

Higher Plasma 5-Hydroxyindoleacetic Acid Levels Are Associated with SSRI-Induced Nausea

Results suggest that SSRI-induced nausea is associated with serotonergic hyperactivity in the gastrointestinal tract and no significant difference was found between the nausea and nonnausea group in terms of p5-HIAA levels before each drug administration.

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

It is shown that 5-HT2C receptor-deficient mice are overweight as a result of abnormal control of feeding behaviour, establishing a role for this receptor in the serotonergic control of appetite.

The serotonin signaling system: from basic understanding to drug development for functional GI disorders.

The initial success encountered with serotonergic agents holds promise for newer and more potent insights and therapies of brain-gut disorders.

Neuropeptide Y induces fasted pattern of duodenal motility via Y(2) receptors in conscious fed rats.

Results indicate that fasted and fed motor activities are regulated processes and that NPY induces fasted activity through Y(2), and possibly Y(4), receptors, which may represent an integrated mechanism linked to the onset of feeding behavior.

Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein.

The results establish an in vivo orexigenic function for NPY and AgRP, mediating the effect of ghrelin, as well as the involvement of the melanocortin pathway inghrelin signaling.

Reduced satiating effect of d-fenfluramine in serotonin 5-HT2C receptor mutant mice

A role for the 5-HT2C receptor in mediating d-fenfluramine-induced satiety is demonstrated and is demonstrated to be a potent inhibitor of the re-uptake of5-HT into nerve terminals and a facilitator of behavioural satiety in mutant mice.