Selective Serotonin 5-HT3 Receptor Antagonists for Postoperative Nausea and Vomiting

@article{Gan2005SelectiveS5,
  title={Selective Serotonin 5-HT3 Receptor Antagonists for Postoperative Nausea and Vomiting},
  author={T. Gan},
  journal={CNS Drugs},
  year={2005},
  volume={19},
  pages={225-238}
}
  • T. Gan
  • Published 2005
  • Medicine
  • CNS Drugs
  • Selective serotonin 5-HT3 receptor antagonists have proven safe and effective for the management of postoperative nausea and vomiting. Dolasetron, granisetron, ondansetron and tropisetron selectively and competitively bind to 5-HT3 receptors, blocking serotonin binding at vagal afferents in the gut and in the regions of the CNS involved in emesis, including the chemoreceptor trigger zone and the nucleus tractus solitarii. Despite their shared mechanism of action, 5-HT3 receptor antagonists have… CONTINUE READING
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    References

    SHOWING 1-10 OF 67 REFERENCES
    Are all 5-HT3 receptor antagonists the same?
    • 81
    Fluoxetine treatment comprises the antiemetic efficacy of ondansetron in cancer patients.
    • O. Koriech
    • Medicine
    • Clinical oncology (Royal College of Radiologists (Great Britain))
    • 1995
    • 29
    Pharmacokinetics and metabolism of the 5-hydroxytryptamine antagonist tropisetron after single oral doses in humans.
    • 30
    The concept of selectivity in 5-HT receptor research.
    • 402
    Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels.
    • 149
    • PDF
    Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes.
    • 233