Selective Serotonin 5-HT3 Receptor Antagonists for Postoperative Nausea and Vomiting

  title={Selective Serotonin 5-HT3 Receptor Antagonists for Postoperative Nausea and Vomiting},
  author={T. Gan},
  journal={CNS Drugs},
  • T. Gan
  • Published 2005
  • Medicine
  • CNS Drugs
  • Selective serotonin 5-HT3 receptor antagonists have proven safe and effective for the management of postoperative nausea and vomiting. Dolasetron, granisetron, ondansetron and tropisetron selectively and competitively bind to 5-HT3 receptors, blocking serotonin binding at vagal afferents in the gut and in the regions of the CNS involved in emesis, including the chemoreceptor trigger zone and the nucleus tractus solitarii. Despite their shared mechanism of action, 5-HT3 receptor antagonists have… CONTINUE READING
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