Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction.

@article{Parisien2002SelectiveSP,
  title={Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction.},
  author={J P Parisien and Joe F. Lau and Jason J. Rodriguez and Christina M. Ulane and Curt M Horvath},
  journal={Journal of virology},
  year={2002},
  volume={76 9},
  pages={4190-8}
}
The alpha/beta interferon (IFN-alpha/beta)-induced STAT signal transduction pathway leading to activation of the ISGF3 transcription complex and subsequent antiviral responses is the target of viral pathogenesis strategies. Members of the Rubulavirus genus of the Paramyxovirus family of RNA viruses have acquired the ability to specifically target either STAT1 or STAT2 for proteolytic degradation as a countermeasure for evading IFN responses. While type II human parainfluenza virus induces STAT2… CONTINUE READING

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