Selective Rep-Cap gene amplification as a mechanism for high-titer recombinant AAV production from stable cell lines.

Abstract

Gene transfer vectors based on adeno-associated virus mediate high-level, stable gene expression in a variety of postmitotic tissues; thus, there is interest in developing improved production systems. We previously described the generation of rAAV producer cell lines that, upon infection with adenovirus, yielded biologically active rAAV particles. In these… (More)

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