Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase*

@inproceedings{Spratt2012SelectiveRO,
  title={Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase*},
  author={Donald E Spratt and Kenneth Wu and J. Kovacev and Zhen-qiang Pan and Gary S. Shaw},
  booktitle={The Journal of biological chemistry},
  year={2012}
}
RING E3 ligases are proteins that must selectively recruit an E2-conjugating enzyme and facilitate ubiquitin transfer to a substrate. It is not clear how a RING E3 ligase differentiates a naked E2 enzyme from the E2∼ubiquitin-conjugated form or how this is altered upon ubiquitin transfer. RING-box protein 1 (Rbx1/ROC1) is a key protein found in the Skp1/Cullin-1/F-box (SCF) E3 ubiquitin ligase complex that functions with the E2 ubiquitin conjugating enzyme CDC34. The solution structure of Rbx1… CONTINUE READING

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