Selective Recognition of RNA Substrates by ADAR Deaminase Domains.

Abstract

Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA and is catalyzed by ADAR1 and ADAR2 in humans. ADAR1 and ADAR2 have different substrate selectivity, which is believed to mainly originate from the proteins' deaminase domains (hADAR1d and hADAR2d, respectively). RNA-seq of the Saccharomyces cerevisiae… (More)
DOI: 10.1021/acs.biochem.7b01100

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