Selective RNA editing and subunit assembly of native glutamate receptors.

@article{Puchalski1994SelectiveRE,
  title={Selective RNA editing and subunit assembly of native glutamate receptors.},
  author={R B Puchalski and J. C. Louis and Nils Brose and Stephen F Traynelis and Jan Egebjerg and Valery Kukekov and Robert J. Wenthold and Scott Warren Rogers and F T Lin and Timothy Moran},
  journal={Neuron},
  year={1994},
  volume={13 1},
  pages={131-47}
}
RNA editing and subunit assembly of ionotropic glutamate receptors (GluRs) were examined in an oligodendrocyte progenitor cell line, CG4, which expresses GluR2-GluR4, GluR6, GluR7, KA1, and KA2. AMPA-evoked currents rapidly desensitize, whereas kainate-evoked currents contain a steady-state component with a nearly linear current-voltage relation and a fast desensitizing component that is inwardly rectifying. The Q/R site is edited > 95% to the arginine codon in GluR2(Q607) mRNA, and < 5% in… CONTINUE READING