Selective Pressure to Increase Charge in Immunodominant Epitopes of the H3 Hemagglutinin Influenza Protein

@inproceedings{Pan2010SelectivePT,
  title={Selective Pressure to Increase Charge in Immunodominant Epitopes of the H3 Hemagglutinin Influenza Protein},
  author={Keyao Pan and Jinxue Long and Haoxin Sun and Gregory J. Tobin and Peter L. Nara and Michael W. Deem},
  booktitle={Journal of Molecular Evolution},
  year={2010}
}
The evolutionary speed and the consequent immune escape of H3N2 influenza A virus make it an interesting evolutionary system. Charged amino acid residues are often significant contributors to the free energy of binding for protein–protein interactions, including antibody–antigen binding and ligand–receptor binding. We used Markov chain theory and maximum… CONTINUE READING