Selective N-type calcium channel antagonist omega conotoxin MVIIA is neuroprotective against hypoxic neurodegeneration in organotypic hippocampal-slice cultures.

@article{Pringle1996SelectiveNC,
  title={Selective N-type calcium channel antagonist omega conotoxin MVIIA is neuroprotective against hypoxic neurodegeneration in organotypic hippocampal-slice cultures.},
  author={Ashley K. Pringle and Christopher D. Benham and Lyann Sim and James Kennedy and Fausto Iannotti and Lars E. Sundstrom},
  journal={Stroke},
  year={1996},
  volume={27 11},
  pages={2124-30}
}
BACKGROUND AND PURPOSE Neuroprotection by antagonists of both L-type and N-type calcium channels occurs in in vivo models of ischemia. The site of action of calcium channel antagonists is unclear, however, and it is likely that a combination of vascular and direct neuronal actions occurs. We have investigated the effects of blocking neuronal calcium channels using an organotypic hippocampal-slice model of ischemia. METHODS Organotypic hippocampal-slice cultures prepared from 10-day-old rats… CONTINUE READING

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