Selective Loss of Estrogen Receptor b in Malignant Human Colon 1

  title={Selective Loss of Estrogen Receptor b in Malignant Human Colon 1},
  author={Eugene F. Foley and Amir Anthony Jazaeri and Margaret A. Shupnik and Omid Jazaeri and Laurel W. Rice},
Epidemiological data suggest a protective effect for estrogen replacement therapy on colon cancer. The estrogen receptor (ER) is required for the action of estrogen. The ERb isoform is functionally similar to ERa but has a distinct pattern of expression and transcriptional response to selective estrogen response modulators. Our goal was to investigate the presence of ERa and ER-b in normal and malignant colon tissue. Human colon cancer tissue and adjacent normal colon tissue were harvested from… CONTINUE READING

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