Selective Inhibitory Effect of Osthenol on Human Cytochrome 2C8

@article{Cho2018SelectiveIE,
  title={Selective Inhibitory Effect of Osthenol on Human Cytochrome 2C8},
  author={P. Cho and W. Nam and Doohyun Lee and T. Lee and Sangkyu Lee},
  journal={Bulletin of The Korean Chemical Society},
  year={2018},
  volume={39},
  pages={801-805}
}
Characterization of osthenol metabolism in vivo and its pharmacokinetics
TLDR
The quantitative method was validated in terms of linearity, accuracy, and precision and the BA of osthenol is low after oral administration, which was determined by LC-HR/MS analysis of the blood sample. Expand
A standardized approach to the evaluation of antivirals against DNA viruses: Orthopox‐, adeno‐, and herpesviruses
TLDR
A standardized approach to evaluating antivirals against lymphotropic herpesviruses and polyomaviruses is presented and together these studies revealed new activities for reference compounds, which have the potential to accelerate the development of broad spectrum therapies for the DNA viruses. Expand
Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol
TLDR
This study elucidated the structure of generated metabolites using a high-resolution quadrupole-orbitrap mass spectrometer and characterized the major human cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferase (UGT) isozymes involved in osthenol metabolism in human liver microsomes (HLMs). Expand

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