Selective Inhibitory Effect of Osthenol on Human Cytochrome 2C8

  title={Selective Inhibitory Effect of Osthenol on Human Cytochrome 2C8},
  author={P. Cho and W. Nam and Doohyun Lee and T. Lee and Sangkyu Lee},
  journal={Bulletin of The Korean Chemical Society},
Characterization of osthenol metabolism in vivo and its pharmacokinetics
The quantitative method was validated in terms of linearity, accuracy, and precision and the BA of osthenol is low after oral administration, which was determined by LC-HR/MS analysis of the blood sample. Expand
A standardized approach to the evaluation of antivirals against DNA viruses: Orthopox‐, adeno‐, and herpesviruses
A standardized approach to evaluating antivirals against lymphotropic herpesviruses and polyomaviruses is presented and together these studies revealed new activities for reference compounds, which have the potential to accelerate the development of broad spectrum therapies for the DNA viruses. Expand
Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol
This study elucidated the structure of generated metabolites using a high-resolution quadrupole-orbitrap mass spectrometer and characterized the major human cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferase (UGT) isozymes involved in osthenol metabolism in human liver microsomes (HLMs). Expand


An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis).
The ingestion of green tea extract or its associated catechins is not expected to result in clinically significant influences on major cytochrome P450 or uridine 5'-diphospho-glucuronosyltransferase enzyme substrates or drugs serving as substrates of P-glycoprotein. Expand
In vivo anti-inflammatory activities of the essential oil from Radix Angelicae dahuricae
EOAD significantly improved hind paw swelling, lowered the adjuvant arthritis score, mitigated synovial hyperplasia, inflammatory cell infiltration, and cartilage destruction in the ankle joint, and reduced the serum levels of inflammatory mediators such as nitric oxide, tumor necrosis factor-α, and prostaglandin E2 as well as serumNitric oxide synthase activity. Expand
Inhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents
This is the first report of CYP3A4 and CYP1A2 inhibition by A. marMelos extract and one of its furanocoumarins, marmelosin. Expand
Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions
Current knowledge on substrates, inhibitors, inducers, and pharmacogenetics of CYP2C8, as well as its role in clinically relevant drug interactions is reviewed. Expand
In vivo prediction of CYP-mediated metabolic interaction potential of formononetin and biochanin A using in vitro human and rat CYP450 inhibition data.
Red clover may be considered safe to be consumed along with co-prescribed medications; however, precaution must be taken while co-administering it with CYP1A2 substrates, because of the drug interaction potential of red clover. Expand
Pharmacokinetic Drug Interaction Studies with Enzalutamide
If a patient requires coadministration of a strong CYP2C8 inhibitor with enzalutamide, then the enzalUTamide dose should be reduced to 80 mg/day, and it is recommended to avoid concomitant use of narrow therapeutic index drugs metabolized by CYP1C9, CYP 2C19, or CYP3A4, as enzyme may decrease their exposure. Expand
Recent trends in preclinical drug–drug interaction studies of flavonoids — Review of case studies, issues and perspectives
Opportunities exist for the combination of flavonoids with suitable anti-cancer drugs to enhance the bioavailability of anti‐cancer drugs and thereby reduce the dose size of the anti‐ cancer drugs and improve its therapeutic index. Expand
A coumarin-specific prenyltransferase catalyzes the crucial biosynthetic reaction for furanocoumarin formation in parsley.
The results demonstrate that a single prenyltransferase, such as PcPT, opens the pathway to linear furanocoumarins in parsley, but may also catalyze the synthesis of osthenol, the first intermediate committed to the angular furanOCoumarin pathway, in other plants. Expand
Expression of Hepatic Drug-Metabolizing Cytochrome P450 Enzymes and Their Intercorrelations: A Meta-Analysis
Positive correlations between the expression levels of some cytochrome P450 enzymes were found in the abundance data, including the following pairs, and these correlations can be used to demonstrate common genetic transcriptional mechanisms. Expand
Potent inhibitory effect of alpha-viniferin on human cytochrome P450.
This is the first investigation conducted on the inhibitory effect of α-viniferin on CYP2C19 and 3A4 in HLMs to predict a potential herb-drug interaction. Expand