Selective Inflammatory Response Induced by Intratracheal and Intravenous Administration of Poly-L-Arginine in Guinea Pig Lungs

@article{Arseneault1999SelectiveIR,
  title={Selective Inflammatory Response Induced by Intratracheal and Intravenous Administration of Poly-L-Arginine in Guinea Pig Lungs},
  author={Daniel Arseneault and Maghni and Pierre Sirois},
  journal={Inflammation},
  year={1999},
  volume={23},
  pages={287-304}
}
Major basic protein (MBP) is a cationic protein found in eosinophil granules that was postulated to participate in the pathogenesis of bronchial asthma. Recently, it has been demonstrated that MBP level in serum or bronchoalveolar lavage (BAL) fluid was correlated with bronchial hyperresponsiveness (BHR) in asthmatics. A number a studies have established that MBP actions could be mimicked by synthetic polycations as poly-L-arginine. In this study, we investigated the effects of intratracheal… CONTINUE READING