Selective Histonedeacetylase Inhibitor M344 Intervenes in HIV-1 Latency through Increasing Histone Acetylation and Activation of NF-kappaB

@inproceedings{Ying2012SelectiveHI,
  title={Selective Histonedeacetylase Inhibitor M344 Intervenes in HIV-1 Latency through Increasing Histone Acetylation and Activation of NF-kappaB},
  author={Hao Ying and Yuhao Zhang and Xin Zhou and Xiying Qu and Pengfei Wang and Sijie Liu and Daru Lu and Huanzhang Zhu},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Histone deacetylase (HDAC) inhibitors present an exciting new approach to activate HIV production from latently infected cells to potentially enhance elimination of these cells and achieve a cure. M344, a novel HDAC inhibitor, shows robust activity in a variety of cancer cells and relatively low toxicity compared to trichostatin A (TSA). However, little is known about the effects and action mechanism of M344 in inducing HIV expression in latently infected cells. METHODOLOGY… CONTINUE READING
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