Selective Factor Xa Inhibition Improves Efficacy of Venous Thromboembolism Prophylaxis in Orthopedic Surgery

@article{Comp2003SelectiveFX,
  title={Selective Factor Xa Inhibition Improves Efficacy of Venous Thromboembolism Prophylaxis in Orthopedic Surgery},
  author={P C Comp},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2003},
  volume={23}
}
  • P. Comp
  • Published 1 June 2003
  • Medicine, Biology
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Venous thromboembolism is a serious, frequent, and potentially fatal complication of major orthopedic surgery. Currently available pharmacologic agents for the prevention of venous thromboembolism in this high‐risk population consist of the oral anticoagulants and the heparin family of antithrombotic agents (unfractionated heparin, low‐molecular‐weight heparin, heparinoids). These classes of agents interfere with the activity of both thrombin and factor Xa (or their respective zymogens) to… 
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