Selective Expression of a Stable Cell Surface Molecule on Type 2 but Not Type 1 Helper T Cells

@article{Xu1998SelectiveEO,
  title={Selective Expression of a Stable Cell Surface Molecule on Type 2 but Not Type 1 Helper T Cells },
  author={D -M. Xu and Woon Ling Chan and Bernard Pui Lam Leung and Fang-ping Huang and Rachel D. Wheeler and David Piedrafita and John H. Robinson and Foo Yew Eddy Liew},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={187},
  pages={787 - 794}
}
T helper cell type 1 (Th1) and 2 (Th2) are central to immune regulation. However, no stable cell surface marker capable of distinguishing and separating these two subsets of CD4(+) cells has yet been found. Using differential display PCR, we have identified a gene encoding a cell membrane bound molecule, originally designated ST2L, T1, DER4, or Fit, expressed constitutively and stably on the surface of murine Th2s, but not Th1s even after stimulation with a range of immunological stimuli… CONTINUE READING
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