Selective Estrogen Receptor Modulators

@article{Haskell2003SelectiveER,
  title={Selective Estrogen Receptor Modulators},
  author={Sally G Haskell},
  journal={Southern Medical Journal},
  year={2003},
  volume={96},
  pages={469-476}
}
  • S. Haskell
  • Published 1 May 2003
  • Biology, Medicine
  • Southern Medical Journal
Because of recent concerns about the long-term risks of estrogen replacement therapy in postmenopausal women, there is growing interest in a group of compounds known as selective estrogen receptor modulators (SERMs). The SERMs bind to estrogen receptors and have tissue-specific effects that allow them to function as estrogen agonists in some tissues and estrogen antagonists in other tissues. There are four SERMs currently marketed in the United States. These include the triphenylethylenes… 
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16 Citations
Background Citations
3
Methods Citations
1

16 Citations

[Changes in the endometrium after tamoxifen therapy].
TLDR
Endometrial hyperplasia or endometrial carcinoma is identified histologically in only a few cases, while other findings related to tamoxifen therapy are stromal decidualisation, regressivehyperplasia, and foci of mucinous, clear cell and serous metaplasia.
Effects of 4-hydroxytamoxifen, raloxifene and ICI 182 780 on survival of uterine cancer cell lines in the presence and absence of exogenous estrogens.
TLDR
The results suggest that the expression of ERalpha, ERbeta and GPR30 are influenced by sex steroids and might play a role in the response of cells to 17beta-estradiol and antiestrogens but are not the only factors involved in this process.
[Effects of tamoxifen on the expression of TGF-beta and p27 proteins in polyps and adjacent endometrium in postmenopausal women].
  • Sheldon Rodrigo BotogoskiS. Lima T. Aoki
  • Medicine, Biology
    Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
  • 2009
TLDR
The TGF-beta expression is not related to the effect of tamoxifen on the growing of endometrial polyps, but the absence of polyps' malignization by tamoxIFen may be explained by the high expression of p27 protein in its glandular epithelium.
Acute tamoxifen treatment increases nitric oxide level but not total antioxidant capacity and adenosine deaminase activity in the plasma of rabbits.
TLDR
In conclusion, acute tamoxifen treatment may not affect the antioxidant status and cellular immunity, as evidenced by unaltered TAC and ADA, however, NO level was increased as early as 24 hours following tamoxIFen treatment.
Andrographolide prevents human breast cancer-induced osteoclastic bone loss via attenuated RANKL signaling
  • Z. ZhaiX. Qu K. Dai
  • Medicine, Biology
    Breast Cancer Research and Treatment
  • 2014
TLDR
Molecular analysis revealed that AP prevented osteoclast function by inhibiting RANKL-induced NF-κB and ERK signaling pathway in lower dose, as well as inducing apoptosis at higher dose (40 μM).
Comparison of mechanisms of angiostasis caused by the anti-inflammatory steroid 5α-tetrahydrocorticosterone versus conventional glucocorticoids.
Efeitos do tamoxifeno sobre a expressão das proteínas TGF-β e p27 em pólipos e endométrio adjacente de mulheres após a menopausa
TLDR
The TGF-beta expression is not related to the effect of tamoxifen on the growing of endometrial polyps, but the absence of polyps' malignization by tamoxIFen may be explained by the high expression of p27 protein in its glandular epithelium.
Zearalenone exposure modulates the expression of ABC transporters and nuclear receptors in pregnant rats and fetal liver.
Efficacy of tamoxifen and thymoquinone on tumor development, lipid peroxidation, and total antioxidant capacity in DMBA induced mammary carcinoma in female Sprague-Dawley rats
TLDR
In conclusion, both TAM and TQ appeared to prevent tumor induction by DMBA and ameliorated the adverse effect of TAM on lipid peroxidation but not body weight gain.
Controlled Ovarian Stimulation Protocols Alter Endometrial Histomorphology and Gene Expression Profiles
Although it is well appreciated that ovarian stimulation protocols for in vitro fertilization (IVF) alter endometrial receptivity, the precise cellular mechanisms are not known. To gain insights into…
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