Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers

@article{Silva2004SelectiveDO,
  title={Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers},
  author={G. Silva and C. Czeisler and Krista L. Niece and E. Beniash and D. Harrington and J. Kessler and S. Stupp},
  journal={Science},
  year={2004},
  volume={303},
  pages={1352 - 1355}
}
Neural progenitor cells were encapsulated in vitro within a three-dimensional network of nanofibers formed by self-assembly of peptide amphiphile molecules. The self-assembly is triggered by mixing cell suspensions in media with dilute aqueous solutions of the molecules, and cells survive the growth of the nanofibers around them. These nanofibers were designed to present to cells the neurite-promoting laminin epitope IKVAV at nearly van der Waals density. Relative to laminin or soluble peptide… Expand
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