Selective Deficits in the Omega-3 Fatty Acid Docosahexaenoic Acid in the Postmortem Orbitofrontal Cortex of Patients with Major Depressive Disorder

@article{McNamara2007SelectiveDI,
  title={Selective Deficits in the Omega-3 Fatty Acid Docosahexaenoic Acid in the Postmortem Orbitofrontal Cortex of Patients with Major Depressive Disorder},
  author={R. McNamara and C. Hahn and R. Jandacek and T. Rider and N. Richtand},
  journal={Biological Psychiatry},
  year={2007},
  volume={62},
  pages={17-24}
}
  • R. McNamara, C. Hahn, +2 authors N. Richtand
  • Published 2007
  • Psychology, Medicine
  • Biological Psychiatry
  • BACKGROUND Epidemiological surveys and peripheral tissue (red blood cells/plasma) fatty acid composition studies suggest that omega-3 fatty acid deficiency is associated with major depressive disorder (MDD) and suicide. It was hypothesized that patients with MDD would exhibit lower frontal cortical concentrations of docosahexaenoic acid (DHA), the principal omega-3 fatty acid in brain, relative to normal controls. METHODS We determined the total fatty acid composition of postmortem… CONTINUE READING
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