Selective Deficits in the Omega-3 Fatty Acid Docosahexaenoic Acid in the Postmortem Orbitofrontal Cortex of Patients with Major Depressive Disorder

@article{McNamara2007SelectiveDI,
  title={Selective Deficits in the Omega-3 Fatty Acid Docosahexaenoic Acid in the Postmortem Orbitofrontal Cortex of Patients with Major Depressive Disorder},
  author={Robert K McNamara and C G Hahn and Ronald James Jandacek and Therese Rider and Patrick Tso and Kevin E. Stanford and Neil M. Richtand},
  journal={Biological Psychiatry},
  year={2007},
  volume={62},
  pages={17-24}
}
Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victims.
...
...

References

SHOWING 1-10 OF 77 REFERENCES
Dietary effects on brain fatty acid composition: the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys.
Rhesus monkeys given pre- and postnatal diets deficient in n-3 essential fatty acids develop low levels of docosahexaenoic acid (22:6 n-3, DHA) in the cerebral cortex and retina and impaired visual
Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study.
TLDR
In community-dwelling elderly persons with depression, fatty acid composition is related to depression, and this relation was not secondary to inflammation, atherosclerosis, or possible confounders, which suggests a direct effect of fatty acids composition on mood.
The dopamine mesocorticolimbic pathway is affected by deficiency in n-3 polyunsaturated fatty acids.
TLDR
Dopamine release was significantly lower in both cerebral areas in n-3 PUFA-deficient rats than in control rats, but this effect was abolished in the frontal cortex and reversed in the nucleus accumbens by reserpine pretreatment, which depletes the dopamine vesicular storage pool.
Fatty acids and homocysteine levels in patients with recurrent depression: an explorative pilot study.
Omega-3 eicosapentaenoic acid in bipolar depression: report of a small open-label study.
TLDR
Although the ultimate utility of omega-3 fatty acids in bipolar depression is still an open question, it is believed that these initial results are encouraging, especially for mild to moderate bipolar depression, and justify the continuing exploration of its use.
...
...