Selective Deficits in the Omega-3 Fatty Acid Docosahexaenoic Acid in the Postmortem Orbitofrontal Cortex of Patients with Major Depressive Disorder

@article{McNamara2007SelectiveDI,
  title={Selective Deficits in the Omega-3 Fatty Acid Docosahexaenoic Acid in the Postmortem Orbitofrontal Cortex of Patients with Major Depressive Disorder},
  author={R. McNamara and C. Hahn and R. Jandacek and T. Rider and P. Tso and K. Stanford and N. Richtand},
  journal={Biological Psychiatry},
  year={2007},
  volume={62},
  pages={17-24}
}
BACKGROUND Epidemiological surveys and peripheral tissue (red blood cells/plasma) fatty acid composition studies suggest that omega-3 fatty acid deficiency is associated with major depressive disorder (MDD) and suicide. It was hypothesized that patients with MDD would exhibit lower frontal cortical concentrations of docosahexaenoic acid (DHA), the principal omega-3 fatty acid in brain, relative to normal controls. METHODS We determined the total fatty acid composition of postmortem… Expand
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Findings add to a growing body of evidence implicating omega-3 fatty acid deficiency as well as the OFC in the pathoaetiology of SZ, and suggest that abnormalities in OFC fatty acid composition may be gender-specific and partially normalized by antipsychotic medications. Expand
Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder
TLDR
The fatty acid composition of postmortem orbitofrontal cortex of patients with bipolar disorder and age-matched normal controls is determined by gas chromatography and significant elevations in arachidonic acid, stearic acid, and palmitic acid conversion/metabolism were observed, and were inversely correlated with DHA composition. Expand
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TLDR
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Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease.
TLDR
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TLDR
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Phospholipid profile in the postmortem hippocampus of patients with schizophrenia and bipolar disorder: no changes in docosahexaenoic acid species.
TLDR
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