Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation

@article{Claessens2001SelectiveDB,
  title={Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation},
  author={Frank Claessens and Guy Verrijdt and E A J M Schoenmakers and Annemie Haelens and Wilfried Rombauts},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2001},
  volume={76},
  pages={23-30}
}
Steroid hormones control many physiological processes by activating specific receptors that act as transcription factors. In vivo, each of these receptors has a specific set of target genes, but in vitro the glucocorticoid, progesterone, mineralocorticoid and androgen receptors (class I receptors) all recognise response elements which are organised as inverted repeats of 5'-TGTTCT-3'-like sequences with a three nucleotide spacer. This poses the question how the in vivo specificity of the… CONTINUE READING
Highly Cited
This paper has 164 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 71 extracted citations

Androgen Signaling in Prostate Cancer.

Cold Spring Harbor perspectives in medicine • 2017
View 1 Excerpt

165 Citations

051015'02'05'09'13'17
Citations per Year
Semantic Scholar estimates that this publication has 165 citations based on the available data.

See our FAQ for additional information.