Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation

@article{Claessens2001SelectiveDB,
  title={Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation},
  author={Frank Claessens and Guy Verrijdt and E A J M Schoenmakers and Annemie Haelens and Wilfried Rombauts},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2001},
  volume={76},
  pages={23-30}
}

• Frank Claessens, Guy Verrijdt, +2 authors Wilfried Rombauts
• Published 2001 in
  The Journal of Steroid Biochemistry and Molecular…
• DOI:10.1016/S0960-0760(00)00154-0

Steroid hormones control many physiological processes by activating specific receptors that act as transcription factors. In vivo, each of these receptors has a specific set of target genes, but in vitro the glucocorticoid, progesterone, mineralocorticoid and androgen receptors (class I receptors) all recognise response elements which are organised as inverted repeats of 5'-TGTTCT-3'-like sequences with a three nucleotide spacer. This poses the question how the in vivo specificity of the… CONTINUE READING

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