Selective D1 and D2 dopamine receptor antagonists produce differential effects on reaction time in the rat.

@article{Mayfield1993SelectiveDA,
  title={Selective D1 and D2 dopamine receptor antagonists produce differential effects on reaction time in the rat.},
  author={Roy Dayne Mayfield and Patrick K. Randall and Waneen W. Spirduso and R. E. Wilcox},
  journal={Pharmacology, biochemistry, and behavior},
  year={1993},
  volume={46 4},
  pages={759-68}
}
The purpose of this investigation was to determine whether selectively blocking D1 and D2 dopamine receptors produces a differential effect on the characteristics (speed and success) of the reaction time response in rats. Animals were shaped to release a lever in response to an auditory/visual stimulus to avoid mild foot shock. The selective D1 antagonist SCH 23390 (0, 70, and 100 micrograms/kg, IP) and the selective D2 antagonists spiperone (0, 1, and 10 micrograms/kg, IP) and haloperidol (0… CONTINUE READING