Selective Constraint on the Upstream Open Reading Frames That Overlap with Coding Sequences in Animals

  title={Selective Constraint on the Upstream Open Reading Frames That Overlap with Coding Sequences in Animals},
  author={Ming-Kung Hsu and Feng-Chi Chen},
  booktitle={PloS one},
Upstream open reading frames (uORFs) are translational regulatory elements located in 5' untranslated regions. They can significantly repress the translation of the downstream coding sequences (CDS), and participate in the spatio-temporal regulations of protein translation. Notwithstanding this biological significance, the selective constraint on uORFs remains underexplored. Particularly, the uORFs that partially overlap with CDS with a different reading frame (overlapping uORFs, or "VuORFs… CONTINUE READING
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