Selective Changes of GABAA Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics

@inproceedings{Jin2011SelectiveCO,
  title={Selective Changes of GABAA Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics},
  author={Zhe Jin and Igor Bazov and Olga V Kononenko and Esa R Korpi and Georgy Bakalkin and B Birnir},
  booktitle={Front. Cell. Neurosci.},
  year={2011}
}
Alcohol dependence is a common chronic relapsing disorder. The development of alcohol dependence has been associated with changes in brain GABA(A) channel-mediated neurotransmission and plasticity. We have examined mRNA expression of the GABA(A) channel subunit genes in three brain regions in individuals with or without alcohol dependence using quantitative real-time PCR assay. The levels of selective GABA(A) channel subunit mRNAs were altered in specific brain regions in alcoholic subjects… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

The role of the orbitofrontal cortex in alcohol use, abuse, and dependence

Progress in Neuro-Psychopharmacology and Biological Psychiatry • 2018
View 3 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 64 references

RNA integrity and the effect on the real-time qRT-PCR performance.

Molecular aspects of medicine • 2006
View 4 Excerpts
Highly Influenced

Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…