Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities.

@article{Sette2008SelectiveCT,
  title={Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities.},
  author={Alessandro Sette and Magdalini Moutaftsi and Juan E. Moyron-Quiroz and Megan M. McCausland and D. Huw Davies and Robert J. Johnston and Bjoern Peters and Mohammed Rafii-El-Idrissi Benhnia and Julia Hoffmann and H Q Su and Kavita Kaur DO Ranjit Singh and David N. Garboczi and Steven Head and Howard Grey and Philip L. Felgner and Shane Crotty},
  journal={Immunity},
  year={2008},
  volume={28 6},
  pages={847-58}
}
Antibody responses are critical components of protective immune responses to many pathogens, but parameters determining which proteins are targeted remain unclear. Vaccination with individual MHC-II-restricted vaccinia virus (VACV, smallpox vaccine) epitopes revealed that CD4(+) T cell help to B cells was surprisingly nontransferable to other virion protein… CONTINUE READING