Selective CCR2‐targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis

  title={Selective CCR2‐targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis},
  author={L. McIntosh and J. L. Barnes and V. L. Barnes and J. Mcdonald},
  journal={Clinical & Experimental Immunology},
  • L. McIntosh, J. L. Barnes, +1 author J. Mcdonald
  • Published 2009
  • Medicine, Biology
  • Clinical & Experimental Immunology
  • The CCL2/CCR2 chemokine/receptor axis directs the chemotaxis of infiltrating monocytes/macrophages and T cells and plays a pivotal role in tissue damage and fibrosis in kidney diseases. The eradication of the activated leucocytes should diminish the production of inflammatory mediators, limit tissue damage and ameliorate disease. A recombinant fusion protein (OPL‐CCL2‐LPM) comprised of the human CCL2 (monocyte chemoattractant protein‐1) chemokine fused to a truncated form of the enzymatically… CONTINUE READING
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