Selective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged Rats

  • John J. Alam
  • Published 2015 in Journal of Alzheimer's disease : JAD


BACKGROUND P38 mitogen activated protein kinase (MAPK) α modulates microglia-mediated inflammatory responses and a number of neuronal physiological processes. OBJECTIVE To evaluate pre-clinically the pharmacological effects in the brain of p38 MAPKα inhibition with a brain-penetrant specific chemical antagonist. METHODS VX-745, a blood-brain barrier… (More)
DOI: 10.3233/JAD-150277


4 Figures and Tables