Selective Bottlenecks Shape Evolutionary Pathways Taken during Mammalian Adaptation of a 1918-like Avian Influenza Virus.

@article{Moncla2016SelectiveBS,
  title={Selective Bottlenecks Shape Evolutionary Pathways Taken during Mammalian Adaptation of a 1918-like Avian Influenza Virus.},
  author={Louise H. Moncla and Gongxun Zhong and Chase W. Nelson and Jorge M. Dinis and James P Mutschler and Austin L. Hughes and Tokiko Watanabe and Yoshihiro Kawaoka and Thomas C Friedrich},
  journal={Cell host & microbe},
  year={2016},
  volume={19 2},
  pages={
          169-80
        }
}
Avian influenza virus reassortants resembling the 1918 human pandemic virus can become transmissible among mammals by acquiring mutations in hemagglutinin (HA) and polymerase. Using the ferret model, we trace the evolutionary pathway by which an avian-like virus evolves the capacity for mammalian replication and airborne transmission. During initial infection, within-host HA diversity increased drastically. Then, airborne transmission fixed two polymerase mutations that do not confer a… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES

Within-host nucleotide diversity of virus populations: insights from next-generation sequencing.

  • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2015
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…