Selective B-cell expression of the MHV-68 latency-associated M2 protein regulates T-dependent antibody response and inhibits apoptosis upon viral infection.

@article{Oliveira2013SelectiveBE,
  title={Selective B-cell expression of the MHV-68 latency-associated M2 protein regulates T-dependent antibody response and inhibits apoptosis upon viral infection.},
  author={Vivian Leite de Oliveira and S{\'i}lvia Cristina Paiva Almeida and Hugo R Soares and R Michael E Parkhouse},
  journal={The Journal of general virology},
  year={2013},
  volume={94 Pt 7},
  pages={
          1613-23
        }
}
To better understand the role of the M2 protein of the murine herpes virus strain 68 (MHV-68) in vivo, B-lymphocyte-restricted, M2-transgenic mice were constructed. The transgenic mice contained normal B-cell subpopulations in bone marrow, lymph nodes and spleen. After immunization with sheep red blood cells, spleens from M2-transgenic mice had increased germinal centres. Transgenic mice responded to the T-cell-dependent antigen keyhole limpet haemocyanin (KLH) with higher levels of secondary… CONTINUE READING

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