Selective Androgen Receptor Modulator (SARM) Treatment Prevents Bone Loss and Reduces Body Fat in Ovariectomized Rats

@article{Kearbey2006SelectiveAR,
  title={Selective Androgen Receptor Modulator (SARM) Treatment Prevents Bone Loss and Reduces Body Fat in Ovariectomized Rats},
  author={Jeffrey D. Kearbey and Wenqing Gao and Ramesh Narayanan and Scott J. Fisher and Di Wu and Duane D. Miller and James T Dalton},
  journal={Pharmaceutical Research},
  year={2006},
  volume={24},
  pages={328-335}
}
This study was conducted to examine the bone and body composition effects of S-4, an aryl-propionamide derived Selective Androgen Receptor Modulator (SARM) in an ovariectomy induced model of accelerated bone loss. One hundred twenty female Sprague–Dawley rats aged to twenty-three weeks were randomly assigned to twelve treatment groups. Drug treatment was initiated immediately following ovariectomy and continued for one hundred twenty days. Whole body bone mineral density (BMD), body composition… CONTINUE READING
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