Selective Alleviation of Compulsive Lever-Pressing in Rats by D1, but not D2, Blockade: Possible Implications for the Involvement of D1 Receptors in Obsessive–Compulsive Disorder

@article{Joel2003SelectiveAO,
  title={Selective Alleviation of Compulsive Lever-Pressing in Rats by D1, but not D2, Blockade: Possible Implications for the Involvement of D1 Receptors in Obsessive–Compulsive Disorder},
  author={Daphna Joel and Julia T Doljansky},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={77-85}
}
Rats undergoing extinction of lever-pressing for food after the attenuation of an external feedback for this behavior exhibit excessive lever-pressing unaccompanied by an attempt to collect a reward. This behavior may be analogous to the excessive and unreasonable behavior seen in obsessive–compulsive disorder. In the present study, we tested the hypothesis that the compulsive behavior induced by signal attenuation is mediated via D1 rather than D2 receptors. Administration of 0.005, 0.01 and 0… CONTINUE READING