Selective Activation of the Transcription Factor NFAT1 by Calcium Microdomains near Ca2+ Release-activated Ca2+ (CRAC) Channels*

  title={Selective Activation of the Transcription Factor NFAT1 by Calcium Microdomains near Ca2+ Release-activated Ca2+ (CRAC) Channels*},
  author={P. Kar and C. Nelson and A. Parekh},
  journal={The Journal of Biological Chemistry},
  pages={14795 - 14803}
  • P. Kar, C. Nelson, A. Parekh
  • Published 2011
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • NFATs are a family of Ca2+-dependent transcription factors that play a central role in the morphogenesis, development, and physiological activities of numerous distinct cell types and organ systems. Here, we visualize NFAT1 movement in and out of the nucleus in response to transient activation of store-operated Ca2+ release-activated Ca2+ (CRAC) channels in nonexcitable cells. We show that NFAT migration is exquisitely sensitive to Ca2+ microdomains near open CRAC channels. Another Ca2… CONTINUE READING
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