Selective Activation of G a o by D 2 L Dopamine Receptors in NS 20 Y Neuroblastoma Cells

@inproceedings{Watts1998SelectiveAO,
  title={Selective Activation of G a o by D 2 L Dopamine Receptors in NS 20 Y Neuroblastoma Cells},
  author={Val J. Watts and Brenda L. Wiens and Medhane G. Cumbay and Minh N. Vu and Rachael Lee Neve and Kim A Neve},
  year={1998}
}
D2L dopamine receptor activation results in rapid inhibition and delayed heterologous sensitization of adenylate cyclase in several host cell types. The D2L dopamine receptor was stably transfected into NS20Y neuroblastoma cells to examine inhibition and sensitization in a neuronal cell environment and to identify the particular G-proteins involved. Acute activation of D2L receptors with the selective D2 agonist quinpirole inhibited forskolin-stimulated cAMP accumulation, whereas prolonged… CONTINUE READING
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