Selective Activation of Epac Increases the Frequency of Submembrane Calcium Sparks in Mesenteric Smooth Muscle Cells

@article{Roberts2013SelectiveAO,
  title={Selective Activation of Epac Increases the Frequency of Submembrane Calcium Sparks in Mesenteric Smooth Muscle Cells},
  author={O. Roberts and T. Kamishima and R. Barrett-Jolley and J. Quayle and C. Dart},
  journal={Biophysical Journal},
  year={2013},
  volume={104},
  pages={614}
}
The relaxation of vascular smooth muscle, which increases blood vessel diameter, is often mediated through vasodilator-induced elevations of intracellular cyclic AMP (cAMP) [1]. The vasculature expresses three distinct cAMP effectors: cAMP-dependent protein kinase (PKA), cyclic nucleotide-gated (CNG) ion channels and the more recently discovered exchange proteins directly activated by cAMP (Epacs) [2]. The mechanisms by which cAMP induces vasorelaxation are thus complex and diverse. Here we… Expand