Selective Accumulation of Raft-Associated Membrane Protein Lat in T Cell Receptor Signaling Assemblies

@article{Harder2000SelectiveAO,
  title={Selective Accumulation of Raft-Associated Membrane Protein Lat in T Cell Receptor Signaling Assemblies},
  author={Thomas Harder and Marina Kuhn},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={151},
  pages={199 - 208}
}
Activation of T cell antigen receptor (TCR) induces tyrosine phosphorylations that mediate the assembly of signaling protein complexes. Moreover, cholesterol-sphingolipid raft membrane domains have been implicated to play a role in TCR signal transduction. Here, we studied the assembly of TCR with signal transduction proteins and raft markers in plasma membrane subdomains of Jurkat T leukemic cells. We employed a novel method to immunoisolate plasma membrane subfragments that were highly… CONTINUE READING

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