• Corpus ID: 86160367

Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14 + NK T Lymphocytes

  title={Selective Ability of Mouse CD1 to Present Glycolipids: $\alpha$-Galactosylceramide Specifically Stimulates V$\alpha$14 + NK T Lymphocytes},
  author={Nicolas Burdin and Laurent Brossay and Yasuhiko Koezuka and Stephen T. Smiley and M. J. Grusby and Ming Gui and Masaru Taniguchi and Kyoko Hayakawa and Mitchell Kronenberg},
  journal={Journal of Immunology},
Mouse CD1 (mCD1) glycoproteins are known to present peptides, while human CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK T cells play critical roles in various immune responses, through the secretion of high amounts of cytokines. This study was initiated to determine whether glycolipids are involved in the autorecognition of mCD1 by NK T cells. α-Galactosylceramide (α-GalCer) was the only glycolipid tested capable of eliciting an mCD1-restricted response by splenic T cells… 

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