Corpus ID: 86160367

Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14 + NK T Lymphocytes

@article{Burdin1998SelectiveAO,
  title={Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14 + NK T Lymphocytes},
  author={N. Burdin and L. Brossay and Y. Koezuka and S. Smiley and M. Grusby and M. Gui and M. Taniguchi and K. Hayakawa and M. Kronenberg},
  journal={Journal of Immunology},
  year={1998},
  volume={161},
  pages={3271-3281}
}
  • N. Burdin, L. Brossay, +6 authors M. Kronenberg
  • Published 1998
  • Biology
  • Journal of Immunology
  • Mouse CD1 (mCD1) glycoproteins are known to present peptides, while human CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK T cells play critical roles in various immune responses, through the secretion of high amounts of cytokines. This study was initiated to determine whether glycolipids are involved in the autorecognition of mCD1 by NK T cells. α-Galactosylceramide (α-GalCer) was the only glycolipid tested capable of eliciting an mCD1-restricted response by splenic T cells… CONTINUE READING
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