• Corpus ID: 86160367

Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14 + NK T Lymphocytes

@article{Burdin1998SelectiveAO,
  title={Selective Ability of Mouse CD1 to Present Glycolipids: $\alpha$-Galactosylceramide Specifically Stimulates V$\alpha$14 + NK T Lymphocytes},
  author={Nicolas Burdin and Laurent Brossay and Yasuhiko Koezuka and Stephen T. Smiley and M. J. Grusby and Ming Gui and Masaru Taniguchi and Kyoko Hayakawa and Mitchell Kronenberg},
  journal={Journal of Immunology},
  year={1998},
  volume={161},
  pages={3271-3281}
}
Mouse CD1 (mCD1) glycoproteins are known to present peptides, while human CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK T cells play critical roles in various immune responses, through the secretion of high amounts of cytokines. This study was initiated to determine whether glycolipids are involved in the autorecognition of mCD1 by NK T cells. α-Galactosylceramide (α-GalCer) was the only glycolipid tested capable of eliciting an mCD1-restricted response by splenic T cells… 
jimmunol.org
402 Citations
Highly Influential Citations
10
Background Citations
85
Methods Citations
20
Results Citations
2

Figures and Tables from this paper

402 Citations

CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution
TLDR
It is shown that mouseNK T cells can recognize human CD1d as well as mouse CD1, and human NK T cells also recognize both CD1 homologues, suggesting that α-GalCer could be a useful agent for modulating human immune responses by activation of the highly conserved NK T cell subset.
Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype.
TLDR
Findings indicate that alpha-GalCer may be useful for modulating immune responses toward a Th2 phenotype during prophylaxis and therapy.
Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers
TLDR
It is shown that tetramers of mouse CD1d loaded with α-GalCer are a sensitive and highly specific reagent for identifying Vα14+ NK T cells and that α- GalCer–specific T lymphocytes are more widely distributed than was previously appreciated.
α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria.
TLDR
The results provide the clear evidence that NKT cells can mediate protection against an intracellular microbial infection.
Tailored design of NKT-stimulatory glycolipids for polarization of immune responses
TLDR
It is the avidity and stability of the ternary complexes of CD1d-glycolipid-iNKT TCR that dictate the polarity and potency of immune responses.
Essential Role of LFA-1 in Activating Th2-Like Responses by α-Galactosylceramide-Activated NKT Cells1
TLDR
First genetic evidence is provided that the adhesion receptor LFA-1 has a crucial role in Th2-polarizing functions of NKT cells following α-GalCer stimulation.
Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids
TLDR
It is shown that glycolipids activated the TCR of NKT cells with phosphorylation of CD3ε, ERK1/2, or CREB, which correlated with their induction of Th1 cytokines, which indicates that α-GalCer analogs can be designed to favor Th1-biased immunity, with greater anticancer efficacy and other immune-enhancing activities than α- GalCer itself.
Immunization with α‐galactosylceramide polarizes CD1‐reactive NK T cells towards Th2 cytokine synthesis
TLDR
Repeated exposure of mice to α‐GalCer induces splenic T cells to secrete IL‐4 and IL‐10 but dramatically reduced levels of IFN‐γ, suggesting that this compound might be useful in the induction of Th2 immune responses and the prevention of chronic inflammatory conditions mediated by Th1 cytokines.
Quantitative and Qualitative Differences in the In Vivo Response of NKT Cells to Distinct α- and β-Anomeric Glycolipids1
TLDR
It is indicated that NKT cells can fine-tune their immune responses to distinct glycolipid Ags in vivo, a property that may be exploited for the development of effective and safe NKT cell-based immunotherapies.
Avidity of CD1d-ligand-receptor ternary complex contributes to T-helper 1 (Th1) polarization and anticancer efficacy
TLDR
It is suggested that CD1d–phenyl glycolipid complexes may interact with the same population of iNKT cells but with higher avidity and stability to drive Th1 polarization, which provides a key to the rational design of Th1 biasedCD1d reactive Glycolipids in the future.
...
...

References

SHOWING 1-10 OF 91 REFERENCES
Mouse CD1 is mainly expressed on hemopoietic-derived cells.
TLDR
The pattern of expression of mCD1 correlates with the distribution of NK1 T cells and is consistent with an important Ag-presenting function for this molecule.
TAP-independent, beta 2-microglobulin-dependent surface expression of functional mouse CD1.1
TLDR
Results indicate that expression of functional mCD1.1 occurs in a beta 2m-dependent, TAP- independent manner.
CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen
TLDR
It is reported that the proliferative and cytotoxic responses of human CD4−8− αβTCR+ T cells specific for Mycobacterium tuberculosis can be restricted by GDlb, one of the four identified protein products of the GDI locus.
Nonclassical behavior of the mouse CD1 class I-like molecule.
The mouse CD1 (mCD1) molecule is a class I-like molecule that is encoded outside of the MHC. We show here that mCD1 shares several properties with Ag-presenting class I molecules, including a…
Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets.
TLDR
It is proposed that at least some of the autoreactive T cells require endosomally derived CD1-bound ligands, and that they are capable of distinguishing between a diverse set of such self-ligands, which might be either autologous lipoglycans or peptides.
Mouse CD1-specific NK1 T cells: development, specificity, and function.
TLDR
The specificity and function of mouse NK1 T cells are reviewed, the relationship of this lineage to mainstream T cells and NK cells is discussed, and the novel regulatory pathway, which straddles the innate and the adaptive immune systems, is discussed.
Requirements for CD1d Recognition by Human Invariant Vα24+ CD4−CD8− T Cells
TLDR
It is demonstrated that human invariant Vα24+ CD4−CD8− T cells, and presumably the homologous murine NK1+ T cell population, are CD1d reactive and functionally distinct from NK cells.
Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice.
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.
TLDR
Glycosylceramide-mediated proliferative responses of Valpha14 NKT cells were abrogated by treatment with chloroquine-concanamycin A or by monoclonal antibodies against CD1d/Vbeta8, CD40/CD40L, or B7/CTLA-4/CD28, but not by interference with the function of a transporter-associated protein.
CD1-restricted T cell recognition of microbial lipoglycan antigens.
TLDR
It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes, which resulted in T cells activated by LAM producing interferon gamma and were cytolytic.
...
...