Corpus ID: 86160367

Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14 + NK T Lymphocytes

  title={Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14 + NK T Lymphocytes},
  author={N. Burdin and L. Brossay and Y. Koezuka and S. Smiley and M. Grusby and M. Gui and M. Taniguchi and K. Hayakawa and M. Kronenberg},
  journal={Journal of Immunology},
  • N. Burdin, L. Brossay, +6 authors M. Kronenberg
  • Published 1998
  • Biology
  • Journal of Immunology
  • Mouse CD1 (mCD1) glycoproteins are known to present peptides, while human CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK T cells play critical roles in various immune responses, through the secretion of high amounts of cytokines. This study was initiated to determine whether glycolipids are involved in the autorecognition of mCD1 by NK T cells. α-Galactosylceramide (α-GalCer) was the only glycolipid tested capable of eliciting an mCD1-restricted response by splenic T cells… CONTINUE READING
    394 Citations
    CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution
    • 644
    • PDF
    Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers
    • 921
    • PDF
    Tailored design of NKT-stimulatory glycolipids for polarization of immune responses
    • 23
    Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids
    • 138
    • PDF
    Avidity of CD1d-ligand-receptor ternary complex contributes to T-helper 1 (Th1) polarization and anticancer efficacy
    • 37
    • PDF
    Quantitative and Qualitative Differences in the In Vivo Response of NKT Cells to Distinct α- and β-Anomeric Glycolipids1
    • 104
    • PDF


    Mouse CD1 is mainly expressed on hemopoietic-derived cells.
    • 263
    Nonclassical behavior of the mouse CD1 class I-like molecule.
    • 69
    Mouse CD1-specific NK1 T cells: development, specificity, and function.
    • 1,442
    Requirements for CD1d Recognition by Human Invariant Vα24+ CD4−CD8− T Cells
    • 491
    • PDF
    CD1-restricted T cell recognition of microbial lipoglycan antigens.
    • 780