Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in mice

@article{Odashima2005SelectiveAA,
  title={Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in mice},
  author={Masaru Odashima and Michiro Otaka and Mario Jin and Koga Komatsu and Isao Wada and Tamotsu Matsuhashi and Youhei Horikawa and Natsumi Hatakeyama and Jinko Oyak{\'e} and Reina Ohba and Joel M Linden and Sumio Watanabe},
  journal={Journal of Gastroenterology},
  year={2005},
  volume={40},
  pages={526-529}
}
d-Galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver injury is an experimental model of fulminant hepatic failure in which tumor necrosis factor-α (TNF-α) plays a pivotal role. We examined the effects of a highly selective adenosine A2A receptor agonist (ATL-146e) on GalN/LPS-induced fulminant hepatic failure. Mice were given an intraperitoneal dose of GalN (800 mg/g body weight)/LPS (100 ng/g body weight) with and without ATL-146e (0.01 µg/kg) treatment. Liver injury was assessed… CONTINUE READING