Selective 5-HT receptor inhibition of glutamatergic and GABAergic synaptic activity in the rat dorsal and median raphe.

@article{Lemos2006Selective5R,
  title={Selective 5-HT receptor inhibition of glutamatergic and GABAergic synaptic activity in the rat dorsal and median raphe.},
  author={Julia C. Lemos and Yu-zhen Pan and Xiaohong Ma and Christophe Lamy and Adaure C Akanwa and Sheryl G. Beck},
  journal={The European journal of neuroscience},
  year={2006},
  volume={24 12},
  pages={3415-30}
}
The dorsal (DR) and median (MR) raphe nuclei contain 5-hydroxytryptamine (5-HT) cell bodies that give rise to the majority of the ascending 5-HT projections to the forebrain. The DR and MR have differential roles in mediating stress, anxiety and depression. Glutamate and GABA activity sculpt putative 5-HT neuronal firing and 5-HT release in a seemingly differential manner in the MR and DR, yet isolated glutamate and GABA activity within the DR and MR has not been systematically characterized… CONTINUE READING