Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues.

@article{Zhang2013SelectivePB,
  title={Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues.},
  author={Hui Zhang and Shotaro Nakajima and Hironori Kato and Liubao Gu and Tatsuya Yoshitomi and Kaoru Nagai and Hideyuki Shinmori and Susumu Kokubo and Masanori Kitamura},
  journal={British journal of pharmacology},
  year={2013},
  volume={170 4},
  pages={822-34}
}
BACKGROUND AND PURPOSE 4-Phenylbutyric acid (4-PBA) is a chemical chaperone that eliminates the accumulation of unfolded proteins in the endoplasmic reticulum (ER). However, its chaperoning ability is often weak and unable to attenuate the unfolded protein response (UPR) in vitro or in vivo. To develop more potent chemical chaperones, we synthesized six analogues of 4-PBA and evaluated their pharmacological actions on the UPR. EXPERIMENTAL APPROACH NRK-52E cells were treated with ER stress… CONTINUE READING

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