Selection pressure on HIV-1 envelope by broadly neutralizing antibodies to the conserved CD4-binding site.

@article{Wu2012SelectionPO,
  title={Selection pressure on HIV-1 envelope by broadly neutralizing antibodies to the conserved CD4-binding site.},
  author={Xue-ling Wu and Charlene Wang and Sijy O'dell and Yuxing Li and Brandon F Keele and Zhongjia Yang and Hiromi Imamichi and Nicole A Doria-Rose and James A Hoxie and Mark Connors and George M. Shaw and Richard T. Wyatt and John R. Mascola},
  journal={Journal of virology},
  year={2012},
  volume={86 10},
  pages={5844-56}
}
The monoclonal antibody (MAb) VRC01 was isolated from a slowly progressing HIV-1-infected donor and was shown to neutralize diverse HIV-1 strains by binding to the conserved CD4 binding site (CD4bs) of gp120. To better understand the virologic factors associated with such antibody development, we characterized HIV-1 envelope (Env) variants from this donor and five other donors who developed broadly neutralizing antibodies. A total of 473 env sequences were obtained by single-genome… CONTINUE READING

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