Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus.

@article{Dowd2009SelectionPF,
  title={Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus.},
  author={Kimberly A. Dowd and Dale M Netski and Xiao-Hong Wang and Andrea L Cox and Stuart C. Ray},
  journal={Gastroenterology},
  year={2009},
  volume={136 7},
  pages={
          2377-86
        }
}
  • Kimberly A. Dowd, Dale M Netski, +2 authors Stuart C. Ray
  • Published in Gastroenterology 2009
  • Biology, Medicine
  • BACKGROUND & AIMS Despite recent characterization of hepatitis C virus-specific neutralizing antibodies, it is not clear to what extent immune pressure from neutralizing antibodies drives viral sequence evolution in vivo. This lack of understanding is particularly evident in acute infection, the phase when elimination or persistence of viral replication is determined and during which the importance of the humoral immune response has been largely discounted. METHODS We analyzed envelope… CONTINUE READING

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