Selection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from Southeast Asia.

@article{Burrows2004SelectionPE,
  title={Selection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from Southeast Asia.},
  author={Jacqueline M. Burrows and Lindell Bromham and Megan Woolfit and Gwena{\"e}l Piganeau and Judy T. Tellam and Geoff Connolly and Natasha Webb and Leith Poulsen and Leanne Cooper and Scott R. Burrows and Denis J. Moss and Sofia Mubarika Haryana and Mun Hon Ng and John Malcolm Nicholls and Rajiv Khanna},
  journal={Journal of virology},
  year={2004},
  volume={78 13},
  pages={7131-7}
}
The geographically constrained distribution of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) in southeast Asian populations suggests that both viral and host genetics may influence disease risk. Although susceptibility loci have been mapped within the human genome, the role of viral genetics in the focal distribution of NPC remains an enigma. Here we report a molecular phylogenetic analysis of an NPC-associated viral oncogene, LMP1, in a large panel of EBV isolates from… CONTINUE READING
18 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…