Selection of ventricular-like cardiomyocytes from ES cells in vitro.

  title={Selection of ventricular-like cardiomyocytes from ES cells in vitro.},
  author={Marcus Christian M{\"u}ller and Bernd K Fleischmann and Stefan Selbert and Guan J Ji and Elmar Endl and Guido Middeler and Oliver J M{\"u}ller and Peter Schlenke and Steffen Frese and Anna M. Wobus and J{\"u}rgen Hescheler and Hugo A. Katus and Wolfgang Michael Franz},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={14 15},
Ischemic disorders of the heart can cause an irreversible loss of cardiomyocytes resulting in a substantial decrease of cardiac output. The therapy of choice is heart transplantation, a technique that is hampered by the low number of donor organs. In the present study, we describe the specific labeling, rapid but gentle purification and characterization of cardiomyocytes derived from mouse pluripotent embryonic stem (ES) cells. To isolate the subpopulation of ventricular-like cardiomyocytes, ES… CONTINUE READING


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