Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form

  title={Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form},
  author={James M. Ogle and Frank V. Murphy and Michael J. Tarry and V Ramakrishnan},
A structural and mechanistic explanation for the selection of tRNAs by the ribosome has been elusive. Here, we report crystal structures of the 30S ribosomal subunit with codon and near-cognate tRNA anticodon stem loops bound at the decoding center and compare affinities of equivalent complexes in solution. In ribosomal interactions with near-cognate tRNA, deviation from Watson-Crick geometry results in uncompensated desolvation of hydrogen-bonding partners at the codon-anticodon minor groove… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 260 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 140 extracted citations

Suppression of premature termination codons as a therapeutic approach.

Critical reviews in biochemistry and molecular biology • 2012
View 7 Excerpts
Highly Influenced

260 Citations

Citations per Year
Semantic Scholar estimates that this publication has 260 citations based on the available data.

See our FAQ for additional information.