Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form

@article{Ogle2002SelectionOT,
  title={Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form},
  author={James M. Ogle and Frank V. Murphy and Michael J. Tarry and V Ramakrishnan},
  journal={Cell},
  year={2002},
  volume={111},
  pages={721-732}
}
A structural and mechanistic explanation for the selection of tRNAs by the ribosome has been elusive. Here, we report crystal structures of the 30S ribosomal subunit with codon and near-cognate tRNA anticodon stem loops bound at the decoding center and compare affinities of equivalent complexes in solution. In ribosomal interactions with near-cognate tRNA, deviation from Watson-Crick geometry results in uncompensated desolvation of hydrogen-bonding partners at the codon-anticodon minor groove… CONTINUE READING
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