Selection of suitable operating conditions to minimize the gradient equilibration time in the separation of drugs by Ultra-High-Pressure Liquid Chromatography with volatile (mass spectrometry-compatible) buffers.

Abstract

Reversed phase gradient elution is the method of choice for pharmaceuticals analysis since it allows reducing the analysis time while improving both the quality of the separation and the detection limits. The current trends are towards faster separations which can be achieved thanks to equipments withstanding ultra-high pressures and/or high temperatures… (More)
DOI: 10.1016/j.chroma.2009.11.059

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Cite this paper

@article{Grivel2010SelectionOS, title={Selection of suitable operating conditions to minimize the gradient equilibration time in the separation of drugs by Ultra-High-Pressure Liquid Chromatography with volatile (mass spectrometry-compatible) buffers.}, author={Candice Grivel and J L Rocca and Davy Guillarme and J. - L. Veuthey and Sabine Heinisch}, journal={Journal of chromatography. A}, year={2010}, volume={1217 4}, pages={459-72} }