Selection of strongly immunogenic "tum-" variants from tumors at high frequency using 5-azacytidine

@article{Frost1984SelectionOS,
  title={Selection of strongly immunogenic "tum-" variants from tumors at high frequency using 5-azacytidine},
  author={Philip Frost and Robert G Liteplo and T P Donaghue and Robert S. Kerbel},
  journal={The Journal of Experimental Medicine},
  year={1984},
  volume={159},
  pages={1491 - 1501}
}
Highly immunogenic "tum-" (non-tumorigenic in normal syngeneic hosts) clonal variants can be selected from a variety of poorly immunogenic and highly tumorigenic mouse cell lines at very high frequencies (e.g., greater than 80%) after treatment in vitro with chemical mutagens such as ethyl methanesulfonate (EMS) or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). We herein demonstrate that the same result can be obtained with the poorly mutagenic cytidine analogue, 5-azacytidine, a strong DNA… CONTINUE READING

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