Selection of stereotyped VH81X-{micro}H chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells.

@article{Kawano2005SelectionOS,
  title={Selection of stereotyped VH81X-\{micro\}H chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells.},
  author={Yohei Kawano and Soichiro Yoshikawa and Yoshiyuki Minegishi and Hajime Karasuyama},
  journal={International immunology},
  year={2005},
  volume={17 7},
  pages={857-67}
}
The pre-B cell receptor (preBCR) plays critical roles in early B cell differentiation. It has been shown that not all muH chains are capable of pairing with surrogate light (SL) chains to form preBCR. Here, we established a novel system to differentially identify two types of early pre-B cell populations in bone marrow and fetal liver of mice, one producing SL-pairing muH chains and the other producing SL-non-pairing muH chains. The former population accounted for 80% of all the early pre-B… CONTINUE READING

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Marginal-zone B cells

Nature Reviews Immunology • 2002

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