Selection of self-reactive T cells in the thymus.

  title={Selection of self-reactive T cells in the thymus.},
  author={Gretta L. Stritesky and Stephen C Jameson and Kristin A Hogquist},
  journal={Annual review of immunology},
On the whole, the healthy adaptive immune system is responsive to foreign antigens and tolerant to self. However, many individual lymphocytes have, and even require, substantial self-reactivity for their particular functions in immunity. In this review, we discuss several populations of lymphocytes that are thought to experience agonist stimulation through the T cell receptor during selection: nTreg cells, iNKT cells, nIELs, and nTh17s. We discuss the nature of this self-reactivity, how it… CONTINUE READING

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