Selection of phage-displayed anti-guinea pig C5 or C5a antibodies and their application in xenotransplantation.

@article{Link1999SelectionOP,
  title={Selection of phage-displayed anti-guinea pig C5 or C5a antibodies and their application in xenotransplantation.},
  author={Charles Link and Heiko Hawlisch and Andreas Meyer zu Vilsendorf and S Gyler{\"u}z and Eckhard Nagel and Joerg Koehl},
  journal={Molecular immunology},
  year={1999},
  volume={36 18},
  pages={1235-47}
}
Xenogeneic liver transplantation in the discordant guinea pig (gp) to rat model results in hyperacute rejection within a few minutes, which is due to activation of the complement system. Currently no antibodies against gp complement factors are available, which allow activation of the gp complement system in serum or complement deposition in tissue to be detected. To close this gap, we started developing single chain Fvs (scFvs) against gpC5 and gpC5a. We generated a combinatorial library of… CONTINUE READING

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