Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods.

@article{Wysocka2007SelectionON,
  title={Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods.},
  author={Magdalena Wysocka and Bozena Kwiatkowska and Marek Rzadkiewicz and Adam Lesner and Krzysztof Rolka},
  journal={Combinatorial chemistry & high throughput screening},
  year={2007},
  volume={10 3},
  pages={
          171-80
        }
}
Chemical synthesis, physicochemical characterization and kinetic investigations of a tetrapeptide library of chromogenic substrates containing the amide of 5-amino-2-nitrobenzoic acid (Anb(5,2)-NH(2)) at their C-termini are reported. Anb(5,2)-NH(2) served as a chromophore released upon enzymatic action. The library consisting of 9567 peptides was synthesized using the portioning-mixing method and was screened against bovine a-chymotrypsin and human leukocyte elastase in solution applying an… CONTINUE READING

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