• Biology, Medicine
  • Published in
    Clinical and experimental…

Selection of natural autoreactive B cells.

  title={Selection of natural autoreactive B cells.},
  author={Richard R. Hardy and Kyoko Hayakawa},
  journal={Clinical and experimental rheumatology},
  volume={33 4 Suppl 92},
Natural antibodies produced by CD5+ B1 B cells include anti-thymocyte autoantibody (ATA). Transgenic mice bearing the Ig-μ heavy chain of a prototypic ATA, V(H)3609Vκ21c, demonstrated a critical requirement for self-antigen in the accumulation of ATA B cells and production of high levels of serum ATA. Further work with ATA-μκ transgenic mice revealed that, while development of most B cells were blocked at an immature stage in spleen, some mature ATA B cells were present. ATA-μκ transgenic mice… CONTINUE READING