Selection of large diversities of antiidiotypic antibody fragments by phage display.

@article{Goletz2002SelectionOL,
  title={Selection of large diversities of antiidiotypic antibody fragments by phage display.},
  author={Steffen Goletz and Peter Astrup Christensen and Peter A. Kristensen and Dietmar Blohm and Ian Tomlinson and Greg Winter and Uwe Karsten},
  journal={Journal of molecular biology},
  year={2002},
  volume={315 5},
  pages={
          1087-97
        }
}
Antiidiotypic antibodies (Ab2) are needed as tools for a better understanding of molecular mimicry and the immunological network, and for many potential applications in the biomedical and pharmaceutical field. Antiidiotypic antibodies mimicking carbohydrate or conformational epitopes (Ab2beta) are of considerable interest as surrogate immunogens for cancer vaccination. However, it has so far been difficult and tedious to produce Ab2s to a given antigen. Here we describe a fast and reliable… CONTINUE READING

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